At least one  8 or 9 seed has a 40% probability of making the Sweet 16, based on the past 25 years, however, it hasn't happened since 2004 when 2 made it.  Remember that the pod system was put in place in 2003.

Based on current RPI and AP Rankings and Kenpom Rankings mis-matches, keep an eye on Maryland.  If they are an 8 or 9 seed, they may be worth taking a bet on.